1. Calamine lotion + nystatin
Pharmacology of combined medication: Calamine lotion combined with nystatin can fully exert the anti-inflammatory, astringent and antipruritic effects of calamine on perianal eczema. It can reduce tissue redness, swelling and exudate. It can also protect the local skin. Nystatin can effectively inhibit the growth and reproduction of fungi. The combination of the two is effective in treating perianal eczema.
Instructions for use: Grind 6 nystatin tablets (dosage is 500,000 units/tablet) into powder and add them to 100 ml of calamine lotion. Shake well before use. Dip a cotton swab in the medicine and apply it gently and evenly to the affected area. After applying the medication, keep the patient's buttocks exposed as much as possible. Apply 4-6 times daily. Before applying the medicine, remove any remaining medicine on the skin and then apply the medicine. Keep the patient in the side-lying position to avoid local pressure.
2. Calamine lotion + clindamycin
Pharmacology of combined medication: Calamine lotion has astringent properties and neutralizes acidic skin secretions. Clindamycin has strong effects against both Gram-positive and Gram-negative bacteria. In addition, it is equally sensitive to non-spore-forming bacteria among anaerobic bacteria. Clindamycin powder is readily soluble in water and has some efficacy in treating acne vulgaris when mixed with calamine lotion and applied topically.
Instructions for use: Add an appropriate amount of clindamycin powder to every 100ml of calamine lotion and mix well before applying topically. Apply topically six to eight times daily for a seven-day course of treatment, generally requiring two to three courses. If the patient does not improve after three courses, discontinue use immediately and seek alternative treatment options.
3. Calamine lotion + prednisone acetate
Pharmacology of combined medication: Calamine has astringent and antipruritic properties. It is effective in treating skin oozing, rashes and itching, etc. Prednisone acetate has anti-infective, anti-allergic, and immunosuppressive properties. Adding prednisone acetate to calamine lotion can enhance the anti-allergic effect and quickly relieve skin allergy symptoms. The combined use of the two drugs can have a certain effect on children's rash, skin flushing, blisters and other symptoms caused by allergies to dressings or adhesive tapes.
Instructions for use: Dissolve 50mg of prednisone acetate completely in 1000ml of calamine lotion and apply it externally once every 6 hours. Use normal saline to remove residual medicine on the child before each application.
4. Calamine lotion + Hydrocortisone butyrate cream
Pharmacology of combined medication: Hydrocortisone butyrate cream binds strongly to steroid receptors. However, its systemic effects are weak. Combining it with calamine lotion can effectively enhance its astringent, anti-inflammatory, and antipruritic properties. This combination is particularly effective in treating infantile eczema. However, infants have a thin skin barrier and high permeability, so corticosteroids can easily penetrate into the body. Therefore, topical medications containing hydrocortisone butyrate are not recommended for long-term use in infants. If the patient experiences poor efficacy after using the drug for three days, the drug should be discontinued immediately. In addition, the combined use of calamine lotion and hydrocortisone butyrate cream for exudative rashes is contraindicated.
Instructions for use: First, apply an appropriate amount of hydrocortisone butyrate cream to the affected area and gently massage for a while. Use once in the morning and evening for five days before discontinuing. Discontinue hydrocortisone butyrate cream and then use calamine lotion. Shake the lotion well and apply to the affected area twice a day, allowing it to dry naturally.
5. Calamine lotion + Loratadine
Pharmacology of combined medication: Calamine lotion was applied to cover the local mucous membranes of the buttocks lesions. It effectively promotes the regeneration of the buttocks mucosal tissue, restoring and maintaining the physiological barrier function of the mucosa. It promotes healing of mucous membranes and accelerates scab formation on the skin. It also has excellent anti-inflammatory and antipruritic properties. Calamine lotion combined with loratadine has a stronger anti-allergic effect. It can effectively relieve the discomfort caused by diaper rash in children.
Instructions for use: Grind three loratadine tablets into a powder and mix thoroughly with calamine lotion. Use a sterile cotton swab to evenly apply the mixture to the affected area from the inside out. Apply once with each diaper change.
6. Calamine lotion + Zinc oxide ointment
Pharmacology of combined medication: Zinc oxide has protective, astringent, and antiseptic properties on wounds. Calamine lotion also has protective, antipruritic, antiseptic, and astringent properties. The combined of these two drugs can enhance wound protection and antibacterial effects. It can also accelerate the improvement of diaper rash.
Instructions for use: Apply zinc oxide ointment evenly to the affected area on the buttocks three times daily, washing the skin after two hours. After changing the diaper, apply calamine lotion three times daily for a seven-day course of treatment.
