Seven drugs should not be used in combination with omeprazole.🈲🈲🈲

Omeprazole is a proton pump inhibitor. It is also the most commonly used gastric acid suppressant drug. It is a fat-soluble weakly basic drug. After oral administration by patients, it will be specifically distributed in the secretory tubules of the parietal cells of the gastric mucosa. A high acid environment will convert it into the active ingredient of sulfenamide. It inhibits the activity of hydrogen-potassium ATPase on the gastric parietal cells to block the secretion of gastric acid and increase the pH of gastric juice. Therefore, its inhibitory effect on gastric acid secretion caused by various reasons is long-lasting and potent. Omeprazole is suitable for stomach diseases such as gastric ulcer and duodenal ulcer.

What diseases can omeprazole be used to treat?

1. Gastroesophageal reflux: These patients experience symptoms such as acid reflux and heartburn. Omeprazole can inhibit the secretion of gastric acid to control the symptoms and promote the recovery of esophagitis.
2. Peptic ulcer: abnormal secretion of gastric acid and pepsin can be treated with omeprazole. It can effectively suppress stomach acid and promote the healing of peptic ulcer. At the same time, it can also relieve various related symptoms and reduce complications.
3. Upper gastrointestinal bleeding: Omeprazole can increase the pH of the stomach and reduce the redissolution of blood clots in the stomach. Therefore, upper gastrointestinal bleeding in patients caused by various diseases can be treated with omeprazole.

Which drugs should not be used in combination with omeprazole?

Acidic drugs: Omeprazole is a weakly basic drug. It decomposes rapidly in an acidic environment. Therefore, omeprazole is often made into enteric-coated tablets or capsules. When acidic drugs and omeprazole are used in combination, a neutralization reaction may occur and affect the efficacy of the drug. Acidic drugs such as ambroxol hydrochloride, ornidazole and vitamin B6 should not be used in combination with omeprazole.

Clopidogrel: It is an anti-platelet aggregation drug. Most proton pump inhibitors reduce the production of the active metabolite of clopidogrel, thereby reducing the efficacy of clopidogrel. Among the proton pump inhibitors, omeprazole has a significant effect on clopidogrel. If clopidogrel needs to be used in combination with a proton pump inhibitor, a proton pump inhibitor with less effect such as rabeprazole or pantoprazole should be used.

Digoxin: It is a commonly used cardiac glycoside drug in clinical practice. Its hydrolysis needs to be carried out in an acidic environment. Therefore, omeprazole inhibits gastric acid secretion, which will increase the pH value in the stomach and reduce the hydrolysis of digoxin. The combination of the two will reduce or eliminate the activity of digoxin.

Iron supplements: Growing children or pregnant women sometimes need to take iron supplements to supplement the iron in the body in order to avoid iron deficiency anemia. However, the stomach needs an acidic environment to absorb iron properly. Because omeprazole inhibits gastric acid secretion, the body cannot absorb iron normally.

Nifedipine: It is a commonly used antihypertensive drug in clinical practice. Omeprazole inhibits the enzymes that metabolize nifedipine, thereby increasing the body's absorption of nifedipine. There is an increased risk of hypotension and the risk of adverse effects.

Ketoconazole: It is an antifungal medicine. The release of its drug effect needs to rely on the secretion of gastric acid. The secretion of gastric acid is inhibited by omeprazole to increase the pH value of the stomach. The release of ketoconazole is thus reduced and the bioavailability is reduced, which in turn weakens the antifungal effect.

Probiotics such as Bifidobacterium and Lactobacillus: They can regulate intestinal flora and improve symptoms such as constipation and diarrhea. These probiotics require an acidic environment to remain active. Therefore, they should not be used in combination with antacids.

Precautions for Omeprazole.

When omeprazole is used for peptic ulcer, 1 to 2 times a day, 20 mg each time, the patient swallows once in the morning or once in the morning and evening. The course of gastric ulcer treatment is generally 4 to 8 weeks. The course of treatment for duodenal ulcer is generally 2 to 4 weeks. When omeprazole is used for gastrinoma, the patient should take 60 mg once a day. The total daily dose is adjusted to 20 to 120 mg according to the patient's condition. If the total daily dose exceeds 80 mg, patients should take it in two divided doses. In order to prevent omeprazole from dissolving in the acidic stomach, it is generally made into enteric-coated tablets or capsules. Enteric-coated preparations are generally recommended to be taken on an empty stomach or before meals. It will ensure that the pH value of the stomach will not be affected by food, which will cause the drug to dissolve and release in the stomach in advance, resulting in ineffectiveness.