People should never drink alcohol while taking these drugs.💀💀💀

Many people already know that drinking alcohol while taking medicine can cause adverse reactions. But you should never drink alcohol while taking the following medicines. In severe cases it can even lead to death.

1. Disulfiram-like reactions occur with cephalosporins and alcohol.

Ethanol is the main component of alcohol. It is converted to acetaldehyde in the liver. Acetaldehyde is converted to acetic acid by the action of acetaldehyde dehydrogenase. Finally, it is converted into carbon dioxide and water and discharged from the body.

Disulfiram is a drug used to stop drinking alcohol. It inhibits acetaldehyde dehydrogenase and reduces the degradation of acetaldehyde. This increases the concentration of acetaldehyde in the body, resulting in an acetaldehyde poisoning reaction. Drinking even a small amount of alcohol while taking disulfiram can cause a strong reaction. It includes headache, dizziness, flushing, shortness of breath, laryngeal edema, nausea, vomiting, increased heart rate, low blood pressure, etc. This reaction is called a disulfiram-like reaction. Cephalosporins also have disulfiram-like effects in the body. It can produce a disulfiram-like reaction. Almost all cephalosporins have been reported to cause disulfiram-like reactions.

In addition, drugs that can cause disulfiram-like reactions include nitroimidazole antibiotics such as chloramphenicol, furazolidone, griseofulvin, metronidazole, secnidazole and tinidazole.

• Cefoperazone and Furazolidone: No alcohol should be consumed 1 day before taken it and up to 5 days after discontinuation.
• Cefuroxime, Ceftriaxone, Cefmetazole, Cefminox and Latamoxef: No alcohol should be consumed 1 day before taken it and up to 1 week after discontinuation.
• Cefmandole, Metronidazole and Tinidazole: No alcohol should be consumed 1 day before taken it and up to 3 days after discontinuation.
• Secnidazole: No alcohol should be consumed 1 day before taken it and up to 1 day after discontinuation.

2. Stomach bleeding and liver failure can occur with antipyretic analgesics and alcohol.

Some people have a headache the day after drinking alcohol and then they treat it with aspirin, acetaminophen or an NSAID. In fact, this is a very wrong usage. Some people have a headache the day after drinking alcohol, and then they treat it with aspirin, acetaminophen, or an NSAID. In fact, this is a very wrong usage. 

The above drugs can irritate the gastric mucosa when used with alcohol. It causes bleeding of the gastric mucosa and causes acute hemorrhagic gastritis. 

Although acetaminophen has few side effects at normal doses, alcohol can increase its liver toxicity. This increases the risk of liver failure.

3. Orthostatic hypotension can occur with antihypertensive drugs and alcohol.

Alcohol increases heart rate and dilates blood vessels. It is synergistic with most antihypertensive drugs and increases the risk of orthostatic hypotension. Drinking alcohol while taking dihydropyridine antihypertensive drugs increases the risk of cardiac arrhythmias, especially nifedipine.

4. Hypoglycemic coma can occur with hypoglycemic drugs and alcohol.

Due to the partial hypoglycemic ability of ethanol and it also slows down the metabolism of hypoglycemic drugs, drinking alcohol while taking hypoglycemic agents increases the risk of hypoglycemia and even hypoglycemic coma.

Sulfonylurea antidiabetic drugs such as glimepiride, glyburide, glipizide, glipizide, and gliclazide also reduce alcohol tolerance in patients. Therefore, it also causes a disulfiram-like reaction.

5. Sedative-hypnotics and alcohol can cause respiratory depression.

Drinking too much alcohol while taking sedative-hypnotics such as diazepam, estazolam, nitrazepam, phenobarbital, zopiclone, and zolpidem can cause respiratory depression and can be fatal. In addition, first-generation antihistamines such as chlorpheniramine, cyproheptadine, and diphenhydramine also inhibit the central system. Therefore, drinking alcohol should be prohibited while taking the above drugs.

6. Seizures can occur with antiepileptic drugs and alcohol.

Phenytoin sodium increases metabolism under the action of ethanol, which reduces blood drug concentration and bioavailability. Drinking alcohol while taking this medicine can cause seizures.

7. Malignant hypertension occurs with monoamine oxidase inhibitors and red wine.

Both endogenous monoamine transmitters (such as norepinephrine, serotonin) and exogenous monoamine substances (such as tyramine) are deactivated by monoamine oxidase. If monoamine oxidase is inhibited, these substances are not degraded. This can cause excessive accumulation of them. It results in toxic reactions such as vasoconstriction and increased blood pressure.

Monoamine oxidase inhibitors commonly used clinically include antibacterial drugs (such as furazolidone, linezolid), anti-tuberculosis drugs (such as isoniazid), antiarrhythmic drugs (such as procaine), anti-Parkinson's disease drugs (such as selegilin), antidepressants (such as moclobemide), etc. Drinking alcohol while taking these drugs can cause toxic reactions such as dizziness, difficulty breathing, abdominal pain and diarrhea. When drinking red wine which contain high tyramine, blood pressure will increase and even intracranial hemorrhage can lead to death.