You should know these things about vitamin B6.👌👌

Vitamin B6 is one of the most widely used vitamin B drugs. What diseases can vitamin B6 be used for prevention and cure? How should vitamin B6 be used? Are there any side effects of vitamin B6? You should know the answers to these questions.👍

Vitamin B6 (Pyridoxine)

What diseases can vitamin B6 be used for?

Vitamin B6 is an important coenzyme in the metabolic transformation of certain amino acids, such as glutamic acid, tryptophan, methionine and dopa.

• Vitamin B6 deficiency: This may be due to excessive processing of food and resulting in the loss of vitamin B6. It can manifest as chapped lips, glossitis, seborrheic dermatitis, and pellagra. It can manifest as chapped lips, glossitis, seborrheic dermatitis, and pellagra. It can be used daily 10-20mg of vitamin B6 for 3 weeks.
• Peripheral neuritis caused by isoniazid: The intermediate metabolite of isoniazid (isoniazone) forms soluble complexes with vitamin B6. This increases the excretion of vitamin B6 by the kidneys. The preventive dose is 10-50 mg of vitamin B6 daily. In the case of isoniazid poisoning, 1000 mg of vitamin B6 (intravenous or intramuscular injection) should be given for every 1000 mg of isoniazid. A daily dose of isoniazid ≤ 5 mg/kg rarely causes vitamin B6 deficiency.
• Hyperhomocysteinemia: Monotherapy is vitamin B6 50-200 mg daily. Combination therapy was vitamin B6 100 mg and folic acid 0.5 mg daily.

In addition, some drugs can also cause vitamin B6 deficiency.

• Antitumor drugs: cytarabine, doxorubicin, docetaxel, lapatinib, capecitabine, etc.
• Immunosuppressants: hormones, cyclosporine, cyclophosphamide, etc.
• Antihypertensive drugs: Hydralazine.
• Antituberculosis drugs: isoniazid, cycloserine.
• Other drugs: Contraceptives and anticonvulsants.

Vitamin B6 cannot be combined with levodopa. It is mainly because vitamin B6 promotes the peripheral conversion of levodopa to dopamine. It reduces the effects of levodopa. However, vitamin B6 can be used in combination with levodopa + benserazide or levodopa + carbidopa. It is mainly because decarboxylase inhibitors (benserazide, carbidopa) reduce the effects of vitamin B6.

Diseases that should not be treated with high doses of vitamin B6.

Vitamin B6 has not proven effective for the following conditions, such as acne and other skin diseases, alcoholism, asthma, kidney stones, mental illness, migraine, premenstrual tension, stimulation of milk secretion, loss of appetite. It is not appropriate to use large doses of vitamin B6 to treat the above-mentioned unproven effective diseases.

Vitamin B6 can cause neurotoxicity.

Vitamin B6 is a pyridine substance. These substances have obvious neurotoxicity. Long-term, excessive use of vitamin B6 can cause peripheral neuritis, abnormal nerve paresthesia, gait instability, numbness of hands and feet, etc. The recommended dosage of vitamin B6 tablets is 10-20 mg per day for adults. It must be taken at the recommended dose. Do not overdose and stop taking the drug after 3 weeks.

Physicians should exercise caution when using vitamin B6 to treat vomiting of pregnancy.

Vitamin B6 has been widely used for vomiting during pregnancy. The recommended usage is oral vitamin B6 3-4 times a day, 10-25mg each time. However, pregnant women receiving large amounts of vitamin B6 can cause vitamin B6-dependent syndrome in newborns. Pregnant women must use it under the guidance of a doctor and do not take it without authorization. The drug should also be discontinued after 3 weeks of treatment. Vitamin B6-dependent syndrome is an inborn structural and functional defect of the metabolic enzyme kynurenase. The activity of that enzyme is only 1% of normal. Vitamin B6 includes six interconvertible pyridoxine, pyridoxamine, pyridoxal and their respective 5-phosphates. Pyridoxal 5-phosphate is an important part of this group. It participates in the metabolism of amino acids, proteins, lipids, nucleic acids and glycogen in vivo as a coenzyme of the enzyme system in decarboxylation and transamination. If it is lacking, it can cause convulsions and peripheral nerve disorders. Therefore, vitamin B6 deficiency can cause biochemical and physiological abnormalities. The need for vitamin B6 in children with this disease is 5 to 10 times that of normal children. A lack of vitamin B6 in the diet during pregnancy can cause seizures in newborns. In addition, because pregnant mothers take excessive doses of vitamin B6 during the pregnancy reaction period. It may also cause the baby to still need to rely on a larger amount of vitamin B6 after birth.

Storage of vitamin B6.

Vitamin B6 is easily soluble in water and gradually deteriorates when exposed to light. Therefore, it requires shading and sealed storage.