How to use Cefdinir?👀

Cefdinir is a semi-synthetic third-generation cephalosporin, which is stable to β-lactamase and has good antibacterial activity against Gram-positive and Gram-negative bacteria. Cefdinir has the advantages of good oral absorption, high antibacterial activity, high blood concentration and wide tissue distribution. It has a good treatment effect on mild to moderate respiratory tract infections and skin and soft tissue infections. It is one of the commonly used clinical antibacterial drugs. Some patients feel very alarmed when they have red urine or red stool after using cefdinir. They may mistakenly think it is hematuria or bloody stool and be confused whether they should continue taking it. The following will explain the precautions for using cefdinir.

1. Strictly comply with medication indications

Before using antibiotics, the first choice should be to clarify whether it is a viral infection or a bacterial infection. Antibacterial drugs can only be applied when a bacterial infection is used. 

Suitable for the following mild and moderate infections caused by sensitive bacteria:

Adults and teenagers

1. Community-acquired pneumonia.
2. Acute attack of chronic bronchitis.
3. Acute maxillary sinusitis.
4. Otitis media.
5. Scarlet fever.
6. Pharyngitis or tonsillitis.
7. Uncomplicated skin and soft tissue infections.

Child

1. Acute otitis media.
2. Pharyngitis or tonsillitis.
3. Uncomplicated skin and soft tissue infections.

2. Dosage

The usual dose for adults is 0.1g once, 3 times a day. The recommended dosage and course of treatment for adults and adolescents (over 13 years old) are as follows: 

• For all infectious diseases, the maximum daily dosage of this medicine is 600mg and 10 days is a course of treatment. One dose daily is equivalent to two doses daily, but twice a day is required for pneumonia and skin infections. If the patient's weight is relatively low, condition is relatively mild or the above-mentioned dosage cannot be tolerated. A 100 mg dose, 3 times a day, can also be used.

Recommended regular dose for children: Orally, 9~18mg/kg a day, taken in 3 divided doses. 

• Children 6 months to 12 years old have acute bacterial otitis media, acute maxillary sinusitis, tonsillitis, pharyngitis, simple skin and soft tissue infections. The dose is 1 time every 12 hours, 7mg/kg each time or 1 time every 24 hours, 14mg/kg each time.
• The dose for children with community-acquired pneumonia is once every 8 hours, 3-6 mg/kg each time, with a maximum dose of 200 mg once.

3. Caution and contraindications

Use with caution:

1. People who have a history of allergies to penicillin or cephalosporin drugs.
2. Those with severe renal impairment.
3. Those with poor eating conditions, non-oral intake of nutrients, severe underlying diseases and cachexia (Vitamin K deficiency may occur when using cefdinir and close observation is required).

Contraindications: 

1. Patients with a history of severe allergies to drugs.

4. Medication method

It can be taken before or after a meal (The absorption of cefdinir after a meal is slightly reduced).

Mainly cause gastrointestinal side effects (such as diarrhea, abdominal pain) and skin side effects (such as rash, itching).

Red urine may appear during medication. When combined with iron-containing foods, red stools may appear. This is normal and you can continue to take the drug.

The following drugs will interact with cefdinir and need to be used at intervals:

• Cefdinir has antibacterial activity, which may reduce the effect of drugs containing live bacteria. If you need to use it in combination, please use it at an interval of 2 hours.
• Medications that need to be taken 2 hours apart: antacids (such as aluminum hydroxide).
• Medicines that need to be taken at least 3 hours apart: iron salt drugs (such as ferrous sulfate, iron citrate, iron hydroxide).
• Medications that need to be taken 4 hours apart: Acetylcysteine.

👉Cefdinir has a broad antibacterial spectrum, high local concentration in inflammatory tissue, high bioavailability, high efficiency and low side effects. It has a good effect on children with mild to moderate infections. Paying attention to the precautions during the administration can ensure the maximum effect of the drug and avoid the risk of medication.