Drugs for varicose veins of the lower extremities.👀

Primary superficial varicose veins of the lower extremities are a common clinical manifestation and the superficial varicose veins of the calf are the most common. The prevalence of varicose veins of the lower extremities is as high as 10-25%, and the prevalence of women is slightly higher than that of men. The patients are mostly athletes, waiters and teachers who stand for a long time. When they are standing, the gravity drops and the blood returns to the heart from the farthest point. If the veins are insufficiency, the veins will expand and become varicose, leading to venous hypertension in the lower extremities.

1. Pathogenesis.

Veins are responsible for bringing blood from all parts of the body back to the heart. To prevent the backflow of blood, there are valves in the veins. If the venous valve is not fully closed, the blood will flow back. It leads to blood stasis in the veins of the lower extremities. The venous lumen will be dilated, irregularly bulged, twisted and degenerated. 

Normal                                    Varicose veins

People who stand for a long time, sit for a long time, smoke and often tight clothing are high-risk groups for varicose veins of the lower extremities.

2. Evaluation.

The early manifestations are soreness and discomfort of the limbs, and the superficial veins are tortuous. As the disease progresses, skin itching, skin pigmentation in the boot area, seborrheic dermatitis, ulcers and even superficial thrombophlebitis, as well as pain along the veins caused by superficial thrombophlebitis, and bleeding from varicose veins can occur.

Clinically, varicose veins are divided into six grades:

1. The first level is the dilation of capillaries. Many women have some red spider web-like capillaries in the thighs and calves.
2. In the second level, the green tendons resembling earthworms are exposed on the calves, with a little protrusion, netting or lump-like, and the number is also significantly increased.
3. The third level is edema in addition to varicose veins, swelling and discomfort after walking for a long time.
4. In the fourth level, hyperpigmentation and eczema will appear. Many patients will go to the dermatologist for treatment, but the external medicine will not be effective. In fact, it is caused by the changes of the great saphenous vein, thickening of the skin, and nutritional disorders.
5. Ulcers will appear on the fifth-level skin, but the ulcers can heal.
6. The sixth level is the most serious. Unhealed skin ulcers usually occur in the medial malleolus. The most serious situation is ulcers, ulcers, hard skin, and blackened whole feet.

3. Oral medicine for varicose veins of lower extremities.

Oral drugs play an important role in the conservative treatment of varicose veins of the lower extremities. 

Mechanism of action:

1. Reduce capillary permeability, anti-inflammatory and anti-exudation.
2. Protect veins, improve vein elasticity and increase vein tension.
3. Anti-oxygen free radicals protect damaged tissue cells.

Relieve clinical symptoms such as venous edema, soft tissue swelling, pain, and thrombophlebitis. The recommended use time is 3-6 months.

Diosmin is a commonly used drug. Take 1 tablet at a time, 2 times a day, at lunch and dinner.

Sodium aescinate is taken 1-2 tablets each time, once in the morning and once in the evening, orally after meals.

4. External medication for varicose veins of lower extremities.

Mucopolysaccharide polysulfate cream

Main ingredient: mucopolysaccharide polysulfate

Mucopolysaccharide polysulfate has anticoagulant effect. It can prevent the formation of superficial thrombus and promote their absorption. It has anti-inflammatory effect. It prevent the development of local inflammation and accelerate the absorption of hematoma.

Usage and dosage: Apply the cream to the skin of the affected area 1-2 times a day.

Compound sodium aescinate gel

Main ingredients: sodium aescinate, diethylamine salicylate.

Sodium aescinate can promote the body to increase the plasma concentration of ACTH and cortisone. It can promote the secretion of PGF2α in the blood vessel wall. It can clear the free radicals in the body, thus play a role in anti-inflammatory, anti-exudation, increase venous tension and speed up venous blood flow. It promotes lymphatic reflux, improve blood circulation and microcirculation, and protect the blood vessel wall.

Diethylamine salicylate can enhance the anti-inflammatory effect and has analgesic effect.

Usage and dosage: Apply the gel to the skin of the affected area once or several times a day. When treating ulcers, apply the gel to the skin around the ulcer to avoid touching the ulcer surface.